C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis
نویسندگان
چکیده
منابع مشابه
C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis
C-X-C motif chemokine 10 (CXCL10) is a crucial pro-inflammatory factor in chronic hepatitis. Autophagy dysregulation is known to contribute to hepatic inflammatory injury. Hence, we investigated the regulatory effect of CXCL10 on the autophagosome-lysosome system during non-alcoholic fatty liver disease (NAFLD) development. The effect of CXCL10 ablation by neutralizing monoclonal antibody (mAb)...
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Other names: CD182; CD183; CKR-L2; CMKAR3; CXC-R3; CXCR-3; GPR9; IP10; IP10-R; Mig-R; MigR HGNC (Hugo): CXCR3 Location: Xq13.1 Note: CXCR3 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (CXCL10), Mig (CXCL9) and I-TAC (CXCL11). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first tw...
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INTRODUCTION C-X-C motif chemokine 10 (CXCL10) is a chemokine that plays a critical role in the infiltration of T cells in autoimmune diseases and is reported to be expressed in muscle tissue of polymyositis. To determine the therapeutic efficacy of CXCL10 blockade, we investigated the role of CXCL10 and the effect of anti-CXCL10 antibody treatment in C protein-induced myositis (CIM), an animal...
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ژورنال
عنوان ژورنال: Theranostics
سال: 2017
ISSN: 1838-7640
DOI: 10.7150/thno.19068